Asymmetric Biomimetic Transamination for Preparation of Tetrafluoroethylene-Containing Amines: An Update

Recent advancements in the asymmetric [1,3]-proton shift reaction for the preparation of amino compounds possessing a tetrafluoroethylene moiety have been reported. We critically discuss the observed stereochemical outcomes with respect to the trifluoromethyl and perfluoroalkyl groups traditionally employed in this reaction. The methodological significance of these results is highlighted as well as noting a potential inaccuracy in the reported enantioselectivities due to the self-disproportionation of enantiomers (SDE) phenomenon.

Keywords: Biomimetic Transamination, [1,3]-Proton Shift Reactions, Asymmetric Synthesis, Fluorine Chemistry, Tetrafluoroethylene Moiety, Self-Disproportionation of Enantiomers (SDE) Phenomenon.